Facial development

Beyond studying eyes, some of our AVN labs also pay attention to surrounding structures. Congratulations to Pranidhi Baddam (PhD Student) from the Graf lab for recent publications in the Journal of Anatomy and Disease Model and Mechanisms. Her work characterizes normal maturation of nasal septum cartilage, and the abnormal midfacial development in mice with neural crest-specific deletion of Bmp7. Credit also to Tiffany Kung and Daniela Roth as students in the Graf lab who contributed to the work.

Baddam P, Kung T, Adesida AB, Graf D. Histological and molecular characterization of the growing nasal septum in mice. J Anat. 2021 Mar;238(3):751-764. doi: 10.1111/joa.13332. Epub 2020 Oct 12. PMID: 33043993; PMCID: PMC7855085.

Baddam P, Biancardi V, Roth DM, Eaton F, Thereza-Bussolaro C, Mandal R, Wishart DS, Barr A, MacLean J, Flores-Mir C, Pagliardini S, Graf D. Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea. Dis Model Mech. 2021 Jan 11:dmm.047738. doi: 10.1242/dmm.047738. Epub ahead of print. PMID: 33431521.